An experimental system for analyzing response to a morphogen gradient.
نویسندگان
چکیده
منابع مشابه
Morphogen gradient formation.
How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then...
متن کاملMultiple Paths to Morphogen Gradient Robustness
Much recent attention has focused on the robustness of morphogen gradients, i.e. the ability of such gradients to resist change in the face of genetic and environmental perturbations. It has been suggested that some of the complex regulatory interactions found in morphogen gradients—feedback control of morphogen responsiveness, countergradients of secreted inhibitors, etc.—exist to enhance robu...
متن کاملDiverse Paths to Morphogen Gradient Robustness
2 Summary The patterning of many developing tissues is orchestrated by gradients of morphogens. Included among the molecular events that drive the formation of morphogen gradients are a variety of elaborate regulatory interactions. It is widely thought that the purpose of such interactions is to make gradients robust—i.e. resistant to change in the face of genetic or environmental perturbations...
متن کاملKinetics of morphogen gradient formation.
In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation ...
متن کاملSpatially distributed morphogen production and morphogen gradient formation.
Partial diferential equations and auxiliary conditions governing the activities of the morphogen Dpp in Drosophila wing imaginal discs were formulated and analyzed as Systems B, R, and C in [7] [9] [10]. All had morphogens produced at the border of anterior and posterior chamber of the wing disc idealized as a point, line, or plane in a one-, two-, or three-dimensional model. In reality, morpho...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.18.9334